Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation

Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation

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dc.contributor.author Blais, Alexandre
dc.contributor.author Islam, Uzma
dc.contributor.author Chakroun, Imane
dc.contributor.author Chu, Alphonse
dc.contributor.author Liu, Yubing
dc.date.accessioned 2011-01-18T14:42:10Z
dc.date.available 2011-01-18T14:42:10Z
dc.date.created 2010 en_US
dc.date.issued 2011-01-18
dc.identifier Nucleic Acids Research, 38(20), 6857-6871. en_US
dc.identifier.other 10.1093/nar/gkq585 en_US
dc.identifier.uri http://hdl.handle.net/10393/19696
dc.description.abstract Precise regulation of gene expression is crucial to myogenesis and is thought to require the cooperation of various transcription factors. On the basis of a bioinformatic analysis of gene regulatory sequences, we hypothesized that myogenic regulatory factors (MRFs), key regulators of skeletal myogenesis, cooperate with members of the SIX family of transcription factors, known to play important roles during embryonic skeletal myogenesis. To this day little is known regarding the exact molecular mechanism by which SIX factors regulate muscle development. We have conducted a functional genomic study of the role played by SIX1 and SIX4 during the differentiation of skeletal myoblasts, a model of adult muscle regeneration. We report that SIX factors cooperate with the members of the MRF family to activate gene expression during myogenic differentiation, and that their function is essential to this process. Our findings also support a model where SIX factors function not only ‘upstream’ of the MRFs during embryogenesis, but also ‘in parallel’ to them during myoblast differentiation. We have identified new essential nodes that depend on SIX factor function, in the myogenesis regulatory network, and have uncovered a novel way by which MRF function is modulated during differentiation. en_US
dc.language.iso en en_US
dc.title Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation en_US
dc.type article en_US

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