| dc.contributor.author |
Azadi, Behnam |
|
| dc.date.accessioned |
2012-01-10T18:10:55Z |
|
| dc.date.available |
2012-01-10T18:10:55Z |
|
| dc.date.created |
2012 |
en_US |
| dc.date.issued |
2012-01-10 |
|
| dc.identifier.uri |
http://hdl.handle.net/10393/20530 |
|
| dc.description.abstract |
The effects of the fenretinide and genistein as single or combined drugs on ovarian cancer proliferation and viability were investigated.
Hypothesis: Co-treatment with genistein will enable a lower dose of fenretinide to be effective in inhibiting the proliferation and survival of ovarian cancer cells.
Methods: Low and high doses of genistein and fenretinide were tested on A2780s and A2780cp cells using trypan blue viable cell count, MTS assay.
Results and conclusions: Unlike low doses of fenretinide, genistein had anti-proliferative effects on both cell lines. There were no additive or synergistic effects of the two compounds. Higher dose treatments induced anti-proliferative effects and apoptotic cell death in both A2780s and A2780cp cells, with a greater sensitivity of A2780s cells to both test compounds.
Overall Conclusion: Genistein and higher doses of fenretinide similarly impair cell cycle progression and induce apoptosis. The anti-proliferative effects of genistein can be affected by co-treatment with fenretinide |
en_US |
| dc.language.iso |
en |
en_US |
| dc.subject |
Ein: Genistein |
en_US |
| dc.subject |
Fen: Fenretinide |
en_US |
| dc.subject |
SM: Soy Milk |
en_US |
| dc.title |
Investigation of the Effects of Genistein and Fenretinide on Ovarian Cancer Cells |
en_US |
| dc.type |
Thèse / Thesis |
en_US |
| dc.faculty.department |
Médecine cellulaire et moléculaire / Cellular and Molecular Medicine |
en_US |
| dc.contributor.supervisor |
Vanderhyden, Barbara |
|
| dc.contributor.supervisor |
Kubow, Stan |
|
| dc.embargo.terms |
immediate |
en_US |
| dc.degree.name |
MSc |
en_US |
| dc.degree.level |
masters |
en_US |
| dc.degree.discipline |
Médecine / Medicine |
en_US |
