| dc.contributor.advisor |
Burton, G., |
en |
| dc.contributor.author |
Pietrzak, Ewa M. |
en |
| dc.date.accessioned |
2009-03-23T14:12:06Z |
|
| dc.date.available |
2009-03-23T14:12:06Z |
|
| dc.date.created |
1993 |
en |
| dc.date.issued |
2009-03-23T14:12:06Z |
|
| dc.identifier.citation |
Source: Masters Abstracts International, Volume: 33-02, page: 0534. |
en |
| dc.identifier.isbn |
9780315896925 |
en |
| dc.identifier.uri |
http://hdl.handle.net/10393/6464 |
|
| dc.description.abstract |
Levels and turnover of vitamin E ($\alpha$-T) were studied in guinea pigs placed for three weeks on a diet containing a scorbutic level of vitamin C and either a low level (LE group) or a high level (HE group) of hexadeuterium-labelled vitamin E (d$\sb6$-RRR-$\alpha$-T acetate). The levels of vitamin C in the ten tissues analyzed declined very rapidly at rates that were the same in both the LE and HE groups, indicating that the level of dietary vitamin E had no effect upon tissue vitamin C levels. On the vitamin C deficient diet, the total $\alpha$-T (d$\sb0$- + d$\sb6$-$\alpha$-T) declined significantly over 21 days in the HE group in two tissues with high P-450 enzyme activity and in one tissue with a high partial pressure of oxygen, whereas on a vitamin C-sufficient diet with the same concentration of vitamin E the levels of total $\alpha$-T remained steady in the same tissues. In the LE "scorbutic" group, the total $\alpha$-T declined only in heart and kidney, whereas in the vitamin C-sufficient LE group there was a decline of total $\alpha$-T in all tissues analyzed except brain. The results show that in guinea pigs, at least, vitamin C is indispensable for proper uptake of vitamin E from the gut and absorption into tissues. Changes of vitamin E levels also were studied in six anatomical regions of the brain of rats subjected to controlled ischemia/reperfusion. Analysis showed that ischemia/reperfusion caused statistically significant losses of vitamin E in all regions, except the pons-medulla, and the extent of loss correlated well with the previously determined deterioration of the blood-brain barrier in the corresponding regions. (Abstract shortened by UMI.) |
en |
| dc.format.extent |
145 p. |
en |
| dc.publisher |
University of Ottawa (Canada). |
en |
| dc.subject.classification |
Biology, Microbiology. |
en |
| dc.title |
Vitamin E as an index of tissue peroxidation: The effect of vitamin C deficiency and ischemia/reperfusion. |
en |
| dc.type |
M.Sc.Thesis (M.Sc.)--University of Ottawa (Canada), 1993. |
en |
