The production of HIV suppressive factors by CD28, CD38 and HLA-DR subpopulations of CD8+ T cells.

The production of HIV suppressive factors by CD28, CD38 and HLA-DR subpopulations of CD8+ T cells.

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dc.contributor.advisor Copeland, Karen, en
dc.contributor.author Jiang, Janina Q. en
dc.date.accessioned 2009-03-23T18:21:04Z
dc.date.available 2009-03-23T18:21:04Z
dc.date.created 2001 en
dc.date.issued 2009-03-23T18:21:04Z
dc.identifier.citation Source: Masters Abstracts International, Volume: 41-05, page: 1413. en
dc.identifier.isbn 9780612765306 en
dc.identifier.uri http://hdl.handle.net/10393/9104
dc.description.abstract We have examined CD8+ sub-populations to determine whether these subsets are critical to the production of CD8+ T cell nonlytic factors. The production of the beta-chemokines MIP-1alpha, MIP-1beta and RANTES, and the chemoattractant cytokine IL-16 were measured in cells derived from 24 HIV-infected and 25 uninfected subjects. Asymptomatic HIV+ subjects (CD4 > 200/ul) produced significantly higher levels of MIP-1alpha and MIP-1beta from CD8+ T cells and some sub-phenotypes. Higher RANTES levels were produced by CD28-, CD38- and HLA-DR+/- sub-phenotypes. However, IL-16 was only modulated in the CD38+ subset in comparison to total CD8+ T cells. Infection of CD8+ T cells and sub-populations resulted in generally increased levels of chemokine and IL-16 production, which dissipated over a 15 day time course. Moreover, CD8+ antiviral factor (CAF) activity, another major component of CD8+ T cell nonlytic suppression factors, was not associated with chemokine production. However, significantly higher levels of CAF were produced by CD38+ and HLA-DR+ sub-populations. In addition, we also showed that in CD8+ T cell populations, the production of MIP-1alpha, MIP-1beta and IL-16 was inversely correlated with virus copy number. These findings shed light on the noncytotoxic responses of CD8+ T cells in controlling the natural course of HIV infection. en
dc.format.extent 85 p. en
dc.publisher University of Ottawa (Canada). en
dc.subject.classification Health Sciences, Immunology. en
dc.title The production of HIV suppressive factors by CD28, CD38 and HLA-DR subpopulations of CD8+ T cells. en
dc.type M.Sc.Thesis (M.Sc.)--University of Ottawa (Canada), 2001. en

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