The Separate and Integrated Influence of Metabo- and Baroreflex Activity on Heat Loss Responses

The Separate and Integrated Influence of Metabo- and Baroreflex Activity on Heat Loss Responses

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dc.contributor.author Binder, Konrad
dc.date.accessioned 2011-11-23T16:29:42Z
dc.date.available 2011-11-23T16:29:42Z
dc.date.created 2011 en_US
dc.date.issued 2011-11-23
dc.identifier.uri http://hdl.handle.net/10393/20436
dc.description.abstract Current knowledge indicates that nonthermal muscle metaboreflex activity plays a critical role in the modulation of skin vasodilation and sweating. However, the mechanisms of control have primarily been studied during isometric handgrip exercise in which muscle metaboreceptor activation is induced by a brief post-exercise ischemia of the upper limb. While the reflex increase in mean arterial pressure associated with this period of ischemia is consistent with the activation of muscle metaboreceptors, the change in baroreflex activity may in itself modulate the response. Thus, we sought to understand how these nonthermal stimuli interact in modulating the control of skin perfusion and sweating under conditions of elevated hyperthermia. Furthermore, we examined the mechanisms responsible for the maintenance of arterial blood pressure under varying levels of heat stress during isometric handgrip exercise. Our study findings indicate that the parallel activation of muscle metaboreceptors and baroreceptors during post-exercise ischemia causes divergent influences on the control of skin blood flow and sweating; and these nonthermal stimuli are dependent on the level of hyperthermia. Moreover, we report that heat stress reduces the increase in arterial blood pressure during isometric handgrip exercise and this attenuation is attributed to a blunted increase in peripheral resistance, since cardiac output increased to similar levels for all heat stress conditions. These results provide important insight and understanding into the role of muscle metabo- and baroreflex activity on the control of skin blood flow and sweating; along with further knowledge into the cardiovascular mechanisms responsible for the regulation of arterial blood pressure during hyperthermia. en_US
dc.language.iso en en_US
dc.subject Heat Stress en_US
dc.subject Isometric Handgrip Exercise en_US
dc.subject Post-exercise Ischemia en_US
dc.subject Thermoregulation en_US
dc.subject Cardiovascular en_US
dc.title The Separate and Integrated Influence of Metabo- and Baroreflex Activity on Heat Loss Responses en_US
dc.type Thèse / Thesis en_US
dc.faculty.department Sciences de l'activité physique / Human Kinetics en_US
dc.contributor.supervisor Kenny, Glen
dc.embargo.terms immediate en_US
dc.degree.name MSc en_US
dc.degree.level masters en_US
dc.degree.discipline Sciences de la santé / Health Sciences en_US

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