Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism

Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism

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dc.contributor.author Chen, Hsiao-Huei
dc.contributor.author Zhou, Xun
dc.contributor.author Gomez-Smith, Mariana
dc.contributor.author Qin, Zhaohong
dc.contributor.author Duquette, Philippe M.
dc.contributor.author Cardenas-Blanco, Arturo
dc.contributor.author Rai, Punarpreet S.
dc.contributor.author Harper, Mary-Ellen
dc.contributor.author Tsai, Eve C.
dc.contributor.author Anisman, Hymie
dc.date.accessioned 2012-02-27T20:35:57Z
dc.date.available 2012-02-27T20:35:57Z
dc.date.created 2012 en_US
dc.date.issued 2012-02-27
dc.identifier Cellular and Molecular Life Sciences, (2012) 69:819–828 en_US
dc.identifier.other 10.1007/s00018-011-0794-3 en_US
dc.identifier.uri http://www.springerlink.com/content/k7231q2141443894/fulltext.pdf en_US
dc.identifier.uri http://hdl.handle.net/10393/20718
dc.description.abstract The LIM domain only 4 (LMO4) protein is expressed in the hypothalamus, but its function there is not known. Using mice with LMO4 ablated in postnatal glutamatergic neurons, including most neurons of the paraventricular (PVN) and ventromedial (VMH) hypothalamic nuclei where LMO4 is expressed, we asked whether LMO4 is required for metabolic homeostasis. LMO4 mutant mice exhibited early onset adiposity. These mice had reduced energy expenditure and impaired thermogenesis together with reduced sympathetic outflow to adipose tissues. The peptide hormone leptin, produced from adipocytes,activates Jak/Stat3 signaling at the hypothalamus to control food intake, energy expenditure, and fat metabolism. Intracerebroventricular infusion of leptin suppressed feeding similarly in LMO4 mutant and control mice.However, leptin-induced fat loss was impaired and activation of Stat3 in the VMH was blunted in these mice. Thus, our study identifies LMO4 as a novel modulator of leptin function in selective hypothalamic nuclei to regulate fat metabolism. en_US
dc.language.iso en en_US
dc.subject Adiposity en_US
dc.subject Obesity en_US
dc.subject Sympathetic outflow en_US
dc.subject Hypothalamus en_US
dc.subject Leptin en_US
dc.title Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism en_US
dc.type Article en_US

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