| dc.contributor.advisor |
Moon, Thomas W., |
en |
| dc.contributor.author |
Lortie, Michel B. |
en |
| dc.date.accessioned |
2009-03-23T13:05:33Z |
|
| dc.date.available |
2009-03-23T13:05:33Z |
|
| dc.date.created |
2002 |
en |
| dc.date.issued |
2009-03-23T13:05:33Z |
|
| dc.identifier.citation |
Source: Masters Abstracts International, Volume: 41-05, page: 1364. |
en |
| dc.identifier.isbn |
9780612766075 |
en |
| dc.identifier.uri |
http://hdl.handle.net/10393/6268 |
|
| dc.description.abstract |
Previous studies showed that beta2-adrenergic agonists (beta 2-AAs) enhanced muscle growth and reduced lipid deposition in animals of agricultural and economical importance, including teleost fish. The goal of the present study was to provide a mechanistic explanation underlying the reported beta2-AA-induced muscle growth in the rainbow trout (Oncorhynchus mykiss). Using radioligand binding assays and adenylyl cyclase/cAMP assays, this study characterized and demonstrated the presence of functional beta2-adrenoceptors (beta2-ARs) on red and white muscle membranes. Trout fed 40 ppm of two beta2-AAs (clenbuterol and ractopamine) for 30 days showed no significant changes in measured body and physiological parameters, beta2-AR numbers or beta2-AR mRNA levels in red or white muscle. However, treatments significantly increased fractional protein synthesis rates in red and white muscle. These studies demonstrate that beta2-AAs impact muscle protein synthesis by mechanisms initiated at the muscle membrane beta 2-AR and include the beta2-AR-signalling pathway in a teleost fish. |
en |
| dc.format.extent |
119 p. |
en |
| dc.publisher |
University of Ottawa (Canada). |
en |
| dc.subject.classification |
Biology, Animal Physiology. |
en |
| dc.title |
The rainbow trout muscle beta(2)-adrenoceptor system: Impact of beta(2)-agonist feeding. |
en |
| dc.type |
M.Sc.Thesis (M.Sc.)--University of Ottawa (Canada), 2002. |
en |
