The rainbow trout muscle beta(2)-adrenoceptor system: Impact of beta(2)-agonist feeding.

The rainbow trout muscle beta(2)-adrenoceptor system: Impact of beta(2)-agonist feeding.

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dc.contributor.advisor Moon, Thomas W., en
dc.contributor.author Lortie, Michel B. en
dc.date.accessioned 2009-03-23T13:05:33Z
dc.date.available 2009-03-23T13:05:33Z
dc.date.created 2002 en
dc.date.issued 2009-03-23T13:05:33Z
dc.identifier.citation Source: Masters Abstracts International, Volume: 41-05, page: 1364. en
dc.identifier.isbn 9780612766075 en
dc.identifier.uri http://hdl.handle.net/10393/6268
dc.description.abstract Previous studies showed that beta2-adrenergic agonists (beta 2-AAs) enhanced muscle growth and reduced lipid deposition in animals of agricultural and economical importance, including teleost fish. The goal of the present study was to provide a mechanistic explanation underlying the reported beta2-AA-induced muscle growth in the rainbow trout (Oncorhynchus mykiss). Using radioligand binding assays and adenylyl cyclase/cAMP assays, this study characterized and demonstrated the presence of functional beta2-adrenoceptors (beta2-ARs) on red and white muscle membranes. Trout fed 40 ppm of two beta2-AAs (clenbuterol and ractopamine) for 30 days showed no significant changes in measured body and physiological parameters, beta2-AR numbers or beta2-AR mRNA levels in red or white muscle. However, treatments significantly increased fractional protein synthesis rates in red and white muscle. These studies demonstrate that beta2-AAs impact muscle protein synthesis by mechanisms initiated at the muscle membrane beta 2-AR and include the beta2-AR-signalling pathway in a teleost fish. en
dc.format.extent 119 p. en
dc.publisher University of Ottawa (Canada). en
dc.subject.classification Biology, Animal Physiology. en
dc.title The rainbow trout muscle beta(2)-adrenoceptor system: Impact of beta(2)-agonist feeding. en
dc.type M.Sc.Thesis (M.Sc.)--University of Ottawa (Canada), 2002. en

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